Studien und Daten:

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1.
Malin, A. J. & Till, C. Exposure to fluoridated water and attention deficit hyperactivity disorder prevalence among children and adolescents in the United States: an ecological association. Environ Health 14, 17 (2015).
1.
Grandjean, P. Developmental fluoride neurotoxicity: an updated review. Environ Health 18, 110 (2019).
1.
Grandjean, P. Developmental fluoride neurotoxicity: an updated review. Environ Health 18, 110 (2019).
1.
Gambetta‐Tessini, K., Mariño, R., Ghanim, A., Calache, H. & Manton, D. Carious lesion severity and demarcated hypomineralized lesions of tooth enamel in schoolchildren from Melbourne, Australia. Australian Dental Journal 63, 365–373 (2018).
1.
Bandeira Lopes, L., Machado, V., Botelho, J. & Haubek, D. Molar-incisor hypomineralization: an umbrella review. Acta Odontologica Scandinavica 79, 359–369 (2021).
1.
Souza, J. F. et al. Molar Incisor Hypomineralisation: Possible aetiological factors in children from urban and rural areas. Eur Arch Paediatr Dent 13, 164–170 (2012).
1.
Sönmez, H., Yıldırım, G. & Bezgin, T. Putative factors associated with molar incisor hypomineralisation: an epidemiological study. Eur Arch Paediatr Dent 14, 375–380 (2013).
1.
Pitiphat, W., Luangchaichaweng, S., Pungchanchaikul, P., Angwaravong, O. & Chansamak, N. Factors associated with molar incisor hypomineralization in T hai children. European J Oral Sciences 122, 265–270 (2014).
1.
Kühnisch, J. et al. Respiratory diseases are associated with molar-incisor hypomineralizations. Swiss Dent. J. SSO 124, 286–93 (2014).
1.
Ghanim, A., Manton, D., Bailey, D., Mariño, R. & Morgan, M. Risk factors in the occurrence of molar–incisor hypomineralization amongst a group of Iraqi children. Int J Paed Dentistry 23, 197–206 (2013).
1.
Allazzam, S. M., Alaki, S. M. & El Meligy, O. A. S. Molar Incisor Hypomineralization, Prevalence, and Etiology. International Journal of Dentistry 2014, 1–8 (2014).
1.
Hočevar, L., Kovač, J., Podkrajšek, K. T., Battelino, S. & Pavlič, A. The possible influence of genetic aetiological factors on molar–incisor hypomineralisation. Archives of Oral Biology 118, 104848 (2020).
1.
Bekes, D. K. Ätiologie und Therapie von MIH-Zähnen.
1.
Bandeira Lopes, L., Machado, V., Botelho, J. & Haubek, D. Molar-incisor hypomineralization: an umbrella review. Acta Odontologica Scandinavica 79, 359–369 (2021).
1.
Serna, C., Vicente, A., Finke, C. & Ortiz, A. J. Drugs related to the etiology of molar incisor hypomineralization. The Journal of the American Dental Association 147, 120–130 (2016).
1.
Fatturi, A. L. et al. A systematic review and meta‐analysis of systemic exposure associated with molar incisor hypomineralization. Comm Dent Oral Epid 47, 407–415 (2019).
1.
Bensi, C., Costacurta, M., Belli, S., Paradiso, D. & Docimo, R. Relationship between preterm birth and developmental defects of enamel: A systematic review and meta‐analysis. Int J Paed Dentistry 30, 676–686 (2020).
1.
Wu, X., Wang, J., Li, Y., Yang, Z. & Zhou, Z. Association of molar incisor hypomineralization with premature birth or low birth weight: systematic review and meta-analysis. The Journal of Maternal-Fetal & Neonatal Medicine 33, 1700–1708 (2020).
1.
Wu, X., Wang, J., Li, Y., Yang, Z. & Zhou, Z. Association of molar incisor hypomineralization with premature birth or low birth weight: systematic review and meta-analysis. The Journal of Maternal-Fetal & Neonatal Medicine 33, 1700–1708 (2020).
1.
Silva, M. J., Scurrah, K. J., Craig, J. M., Manton, D. J. & Kilpatrick, N. Etiology of molar incisor hypomineralization – A systematic review. Comm Dent Oral Epid 44, 342–353 (2016).
1.
Yi, X. et al. Prevalence of MIH in children aged 12 to 15 years in Beijing, China. Clin Oral Invest 25, 355–361 (2021).
1.
Gambetta‐Tessini, K., Mariño, R., Ghanim, A., Calache, H. & Manton, D. Carious lesion severity and demarcated hypomineralized lesions of tooth enamel in schoolchildren from Melbourne, Australia. Australian Dental Journal 63, 365–373 (2018).
1.
Rai, P. M. et al. Prevalence of Molar Incisor Hypomineralization among School Children Aged 9 to 12 Years in Virajpet, Karnataka, India. Open Access Maced J Med Sci 7, 1042–1046 (2019).
1.
Bhaskar, S. & Hegde, S. Molar-incisor hypomineralization: Prevalence, severity and clinical characteristics in 8- to 13-year-old children of Udaipur, India. J Indian Soc Pedod Prev Dent 32, 322 (2014).
1.
Da Costa‐Silva, C. M. et al. Molar incisor hypomineralization: prevalence, severity and clinical consequences in Brazilian children. Int J Paed Dentistry 20, 426–434 (2010).
1.
Davenport, M. et al. Prevalence of molar-incisor hypomineralization in Milwaukee, Wisconsin, USA: a pilot study. CCIDE Volume 11, 109–117 (2019).
1.
Navarro, N. P. & Buldur, B. Worldwide prevalence of molar-incisor hypomineralization: A literature review. Contemp Pediatr Dent 5, (2024).
1.
Dulla, J. A. & Meyer-Lückel, H. Molar-incisor hypomineralisation: narrative review on etiology, epidemiology, diagnostics and treatment decision. Swiss Dent. J. SSO 131, 886–895 (2021).
1.
Weerheijm, K. L., Jälevik, B. & Alaluusua, S. Molar incisor hypomineralisation. Eur J Paediatr Dent 2, 114–120 (2003).
1.
Mangum, J. E., Crombie, F. A., Kilpatrick, N., Manton, D. J. & Hubbard, M. J. Surface Integrity Governs the Proteome of Hypomineralized Enamel. J Dent Res 89, 1160–1165 (2010).
1.
Robinson, C., Brookes, S. J., Kirkham, J., Bonass, W. A. & Shore, R. C. Crystal Growth in Dental Enamel: the Role of Amelogenins and Albumin. Adv Dent Res. 10, 173–180 (1996).
1.
Weerheijm, K. L., Jälevik, B. & Alaluusua, S. Molar–Incisor Hypomineralisation. Caries Res 35, 390–391 (2001).
1.
Alaluusua, S. Aetiology of Molar-Incisor Hypomineralisation: A systematic review. Eur Arch Paediatr Dent 11, 53–58 (2010).
1.
Lygidakis, N. A. et al. Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document. Eur Arch Paediatr Dent 23, 3–21 (2022).
1.
Fehlauer, B. Kreidezähne verstehen Hintergründe und Zusammenhänge im menschlichen Entwicklungsprozess - Eine integrative und interdisziplinäre Perspektive. (Lehmanns Media, Berlin, 2025).
1.
Robinson, C. Enamel maturation: a brief background with implications for some enamel dysplasias. Front. Physiol. 5, 00388 (2014).
1.
Proffit, W. R. & Fields, H. W. Contemporary Orthodontics. (Mosby, St. Louis, 2000).
1.
Maeda, H. Aging and senescence of dental pulp and hard tissues of the tooth. Front Cell Dev Biol 8, 605996 (2020).
1.
Institut der Deutschen Zahnärzte. Sechste Deutsche Mundgesundheitsstudie (DMS 6). (Institut der Deutschen Zahnärzte, Berlin, 2025).
1.
Iheozor-Ejiofor, Z. et al. Water fluoridation for the prevention of dental caries. Cochrane Database Syst Rev CD010856 (2015) http://doi.org/10.1002/14651858.CD010856.
1.
Featherstone, J. D. B. The continuum of dental caries—evidence for a dynamic disease process. J Dent Res 83, 39–42 (2004).
1.
DenBesten, P. & Li, W. Chronic fluoride toxicity: dental fluorosis. in Monographs in Oral Science (ed. Buzalaf, M. A. R.) vol. 22 81–96 (S. Karger AG, Basel, 2011).
1.
Bekes, K. Molaren-Inzisiven-Hypomineralisation. (Quintessenz Verlag, Berlin, 2021).
1.
Alrehaili, R., Khalil, A. & Mergami, J. Current knowledge of the etiology and management of molar incisor hypomineralization in children: a narrative review. Cureus https://doi.org/10.7759/cureus.74770 (2024) doi:10.7759/cureus.74770.
1.
Gil-Bona, A. & Bidlack, F. B. Tooth enamel and its dynamic protein matrix. IJMS 21, 4458 (2020).
1.
Hubbard, M. J., Mangum, J. E., Perez, V. A. & Williams, R. A breakthrough in understanding the pathogenesis of molar hypomineralisation: the mineralisation-poisoning model. Front. Physiol. 12, 802833 (2021).
1.
Lunt, R. C. & Law, D. B. A review of the chronology of calcification of deciduous teeth. J Am Dent Assoc 89, 599–606 (1974).
1.
Waes, H. van & Stöckli, P. Kinderzahnmedizin. (Thieme, Stuttgart, 2001).
1.
Castiblanco Rubio, G. A. Pathogenesis of dental fluorosis: biochemical and cellular mechanisms. Rev Fac Odontol 28, 408–421 (2017).
1.
Kabartai, F., Hoffmann, T. & Hannig, C. The physiologic sclerotic dentin: a literature-based hypothesis. Med Hypotheses 85, 887–890 (2015).
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1.
Malin, A. J. & Till, C. Exposure to fluoridated water and attention deficit hyperactivity disorder prevalence among children and adolescents in the United States: an ecological association. Environ Health 14, 17 (2015).
1.
Grandjean, P. Developmental fluoride neurotoxicity: an updated review. Environ Health 18, 110 (2019).
1.
Grandjean, P. Developmental fluoride neurotoxicity: an updated review. Environ Health 18, 110 (2019).
1.
Gambetta‐Tessini, K., Mariño, R., Ghanim, A., Calache, H. & Manton, D. Carious lesion severity and demarcated hypomineralized lesions of tooth enamel in schoolchildren from Melbourne, Australia. Australian Dental Journal 63, 365–373 (2018).
1.
Bandeira Lopes, L., Machado, V., Botelho, J. & Haubek, D. Molar-incisor hypomineralization: an umbrella review. Acta Odontologica Scandinavica 79, 359–369 (2021).
1.
Souza, J. F. et al. Molar Incisor Hypomineralisation: Possible aetiological factors in children from urban and rural areas. Eur Arch Paediatr Dent 13, 164–170 (2012).
1.
Sönmez, H., Yıldırım, G. & Bezgin, T. Putative factors associated with molar incisor hypomineralisation: an epidemiological study. Eur Arch Paediatr Dent 14, 375–380 (2013).
1.
Pitiphat, W., Luangchaichaweng, S., Pungchanchaikul, P., Angwaravong, O. & Chansamak, N. Factors associated with molar incisor hypomineralization in T hai children. European J Oral Sciences 122, 265–270 (2014).
1.
Kühnisch, J. et al. Respiratory diseases are associated with molar-incisor hypomineralizations. Swiss Dent. J. SSO 124, 286–93 (2014).
1.
Ghanim, A., Manton, D., Bailey, D., Mariño, R. & Morgan, M. Risk factors in the occurrence of molar–incisor hypomineralization amongst a group of Iraqi children. Int J Paed Dentistry 23, 197–206 (2013).
1.
Allazzam, S. M., Alaki, S. M. & El Meligy, O. A. S. Molar Incisor Hypomineralization, Prevalence, and Etiology. International Journal of Dentistry 2014, 1–8 (2014).
1.
Hočevar, L., Kovač, J., Podkrajšek, K. T., Battelino, S. & Pavlič, A. The possible influence of genetic aetiological factors on molar–incisor hypomineralisation. Archives of Oral Biology 118, 104848 (2020).
1.
Bekes, D. K. Ätiologie und Therapie von MIH-Zähnen.
1.
Bandeira Lopes, L., Machado, V., Botelho, J. & Haubek, D. Molar-incisor hypomineralization: an umbrella review. Acta Odontologica Scandinavica 79, 359–369 (2021).
1.
Serna, C., Vicente, A., Finke, C. & Ortiz, A. J. Drugs related to the etiology of molar incisor hypomineralization. The Journal of the American Dental Association 147, 120–130 (2016).
1.
Fatturi, A. L. et al. A systematic review and meta‐analysis of systemic exposure associated with molar incisor hypomineralization. Comm Dent Oral Epid 47, 407–415 (2019).
1.
Bensi, C., Costacurta, M., Belli, S., Paradiso, D. & Docimo, R. Relationship between preterm birth and developmental defects of enamel: A systematic review and meta‐analysis. Int J Paed Dentistry 30, 676–686 (2020).
1.
Wu, X., Wang, J., Li, Y., Yang, Z. & Zhou, Z. Association of molar incisor hypomineralization with premature birth or low birth weight: systematic review and meta-analysis. The Journal of Maternal-Fetal & Neonatal Medicine 33, 1700–1708 (2020).
1.
Wu, X., Wang, J., Li, Y., Yang, Z. & Zhou, Z. Association of molar incisor hypomineralization with premature birth or low birth weight: systematic review and meta-analysis. The Journal of Maternal-Fetal & Neonatal Medicine 33, 1700–1708 (2020).
1.
Silva, M. J., Scurrah, K. J., Craig, J. M., Manton, D. J. & Kilpatrick, N. Etiology of molar incisor hypomineralization – A systematic review. Comm Dent Oral Epid 44, 342–353 (2016).
1.
Yi, X. et al. Prevalence of MIH in children aged 12 to 15 years in Beijing, China. Clin Oral Invest 25, 355–361 (2021).
1.
Gambetta‐Tessini, K., Mariño, R., Ghanim, A., Calache, H. & Manton, D. Carious lesion severity and demarcated hypomineralized lesions of tooth enamel in schoolchildren from Melbourne, Australia. Australian Dental Journal 63, 365–373 (2018).
1.
Rai, P. M. et al. Prevalence of Molar Incisor Hypomineralization among School Children Aged 9 to 12 Years in Virajpet, Karnataka, India. Open Access Maced J Med Sci 7, 1042–1046 (2019).
1.
Bhaskar, S. & Hegde, S. Molar-incisor hypomineralization: Prevalence, severity and clinical characteristics in 8- to 13-year-old children of Udaipur, India. J Indian Soc Pedod Prev Dent 32, 322 (2014).
1.
Da Costa‐Silva, C. M. et al. Molar incisor hypomineralization: prevalence, severity and clinical consequences in Brazilian children. Int J Paed Dentistry 20, 426–434 (2010).
1.
Davenport, M. et al. Prevalence of molar-incisor hypomineralization in Milwaukee, Wisconsin, USA: a pilot study. CCIDE Volume 11, 109–117 (2019).
1.
Navarro, N. P. & Buldur, B. Worldwide prevalence of molar-incisor hypomineralization: A literature review. Contemp Pediatr Dent 5, (2024).
1.
Dulla, J. A. & Meyer-Lückel, H. Molar-incisor hypomineralisation: narrative review on etiology, epidemiology, diagnostics and treatment decision. Swiss Dent. J. SSO 131, 886–895 (2021).
1.
Weerheijm, K. L., Jälevik, B. & Alaluusua, S. Molar incisor hypomineralisation. Eur J Paediatr Dent 2, 114–120 (2003).
1.
Mangum, J. E., Crombie, F. A., Kilpatrick, N., Manton, D. J. & Hubbard, M. J. Surface Integrity Governs the Proteome of Hypomineralized Enamel. J Dent Res 89, 1160–1165 (2010).
1.
Robinson, C., Brookes, S. J., Kirkham, J., Bonass, W. A. & Shore, R. C. Crystal Growth in Dental Enamel: the Role of Amelogenins and Albumin. Adv Dent Res. 10, 173–180 (1996).
1.
Weerheijm, K. L., Jälevik, B. & Alaluusua, S. Molar–Incisor Hypomineralisation. Caries Res 35, 390–391 (2001).
1.
Alaluusua, S. Aetiology of Molar-Incisor Hypomineralisation: A systematic review. Eur Arch Paediatr Dent 11, 53–58 (2010).
1.
Lygidakis, N. A. et al. Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document. Eur Arch Paediatr Dent 23, 3–21 (2022).
1.
Fehlauer, B. Kreidezähne verstehen Hintergründe und Zusammenhänge im menschlichen Entwicklungsprozess - Eine integrative und interdisziplinäre Perspektive. (Lehmanns Media, Berlin, 2025).
1.
Robinson, C. Enamel maturation: a brief background with implications for some enamel dysplasias. Front. Physiol. 5, 00388 (2014).
1.
Proffit, W. R. & Fields, H. W. Contemporary Orthodontics. (Mosby, St. Louis, 2000).
1.
Maeda, H. Aging and senescence of dental pulp and hard tissues of the tooth. Front Cell Dev Biol 8, 605996 (2020).
1.
Institut der Deutschen Zahnärzte. Sechste Deutsche Mundgesundheitsstudie (DMS 6). (Institut der Deutschen Zahnärzte, Berlin, 2025).
1.
Iheozor-Ejiofor, Z. et al. Water fluoridation for the prevention of dental caries. Cochrane Database Syst Rev CD010856 (2015) http://doi.org/10.1002/14651858.CD010856.
1.
Featherstone, J. D. B. The continuum of dental caries—evidence for a dynamic disease process. J Dent Res 83, 39–42 (2004).
1.
DenBesten, P. & Li, W. Chronic fluoride toxicity: dental fluorosis. in Monographs in Oral Science (ed. Buzalaf, M. A. R.) vol. 22 81–96 (S. Karger AG, Basel, 2011).
1.
Bekes, K. Molaren-Inzisiven-Hypomineralisation. (Quintessenz Verlag, Berlin, 2021).
1.
Alrehaili, R., Khalil, A. & Mergami, J. Current knowledge of the etiology and management of molar incisor hypomineralization in children: a narrative review. Cureus https://doi.org/10.7759/cureus.74770 (2024) doi:10.7759/cureus.74770.
1.
Gil-Bona, A. & Bidlack, F. B. Tooth enamel and its dynamic protein matrix. IJMS 21, 4458 (2020).
1.
Hubbard, M. J., Mangum, J. E., Perez, V. A. & Williams, R. A breakthrough in understanding the pathogenesis of molar hypomineralisation: the mineralisation-poisoning model. Front. Physiol. 12, 802833 (2021).
1.
Lunt, R. C. & Law, D. B. A review of the chronology of calcification of deciduous teeth. J Am Dent Assoc 89, 599–606 (1974).
1.
Waes, H. van & Stöckli, P. Kinderzahnmedizin. (Thieme, Stuttgart, 2001).
1.
Castiblanco Rubio, G. A. Pathogenesis of dental fluorosis: biochemical and cellular mechanisms. Rev Fac Odontol 28, 408–421 (2017).
1.
Kabartai, F., Hoffmann, T. & Hannig, C. The physiologic sclerotic dentin: a literature-based hypothesis. Med Hypotheses 85, 887–890 (2015).
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